Human blood consists of a number of blood cells: plasma, erythrocytes, leukocytes and thrombocytes(platelets). As they travel through your blood stream and the vein wall is not punctured the thrombocytes are inactive. When the vein wall is punctured, thrombocytes begin to release growth and anti-inflammatory factor proteins. These factors support healing process in tissues of musculoskeletal system. When these factors are injected directly into injured tissues, repair and regeneration of cartilage, tendons, muscles, bones and skin are promoted and accelerated. There is a gradual improvement of condition, pain relief and increase in mobility of affected site. Chronic stage of injury or disease is never reached.
The ACP treatment is a very efficient and successful therapy as evidenced not only by large numbers of patients who got their active lives back but also by numerous studies and publications. Increased concentrations of thrombocytes, growth and anti-inflammatory growth factors in ACP have been confirmed by scientific research and studies.
Growth factors concentrations in ACP
PDGF AB (Platelet derived growth factor AB) -25 fold increase
PDGF BB (Platelet derived growth factor BB) - 6 fold increase
TGF beta 1+2 (Transforming growth factor beta) - 4 fold increase
IGF 1 (Insulin-like growth factor) - 1 fold increase
EGF (Epidermal growth factor) - 5 fold increase
VEGF (Vascular endothelial growth factor) – 11 fold increase
GROWTH FACTORS AND THEIR EFFECTS
- induce proliferation and differentiation of different cell types(stem cells, osteoblasts, epidermal cells)
- increase the amount of collagen, proteoglycans and tissue inhibitors of metalloproteinases
- stimulate DNA synthesis
- stimulate angiogenesis (forming of new blood vessels)
- stimulate chemotaxis-movement of cells